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Just a few years ago at a patient workshop for infertile couples, a woman asked a speaker, “Does the age of the man have an effect on pregnancy outcome?” Surprisingly, the physician said, “Sperm are just like wine – the older the better.” This view is very old school and simply incorrect!
While maternal age over 35 years is a well-known risk factor for decreased fertility, it has clearly been demonstrated that sperm DNA fragmentation increases with age. If the man of a TTC couple is over 40 yrs and/or has experienced infertility and/or miscarriages, do an SCSA test to determine if this is the cause.
Des études montrent que la fragmentation de l’ADN augmente avec l’âge (Wyrobek et al., Evenson et Wixon, 2006). Dans une étude clinique de 17,000 IIU cycles (Belloc et al., 2008) (Belloc et al. (2008) RBM En-ligne 17 :392-397), le taux général de grossesse était 12.7% par cycle mais a diminué de 14.4% (des hommes jusqu’au 30 ans) à 8.9% (des hommes de plus de 42 ans). Notamment, le taux de fausse couche a augmenté plus de quatre fois de 11.1% à 45.6%. Cela est compatible avec les données montrent que les hommes de couples ayant de deux ou plus fausses couches ont présenté quatre fois plus de fragmentation de l’ADN spermatique. (D Carroll). Évidemment, l’intégrité de l’ADN spermatique masculin varie d’une personne à l’autre. Vérifiez de quel côté est votre mari.
Passer à l’action : Réalisez un test SCSA pour déterminer la cause de chacune des correspondances suivantes : l’âge supérieur à 40 ans et/ou antécédents d’infertilité et/ou fausse couche.
While maternal age over 35 years is a well-known risk factor for decreased fertility, it has clearly been demonstrated that sperm DNA fragmentation increases with age (Wyrobek et al, Evenson and Wixon, 2006). In a clinical study of 17,000 IUI cycles (Belloc et al, 2008) (Belloc et al (2008) RBM Online 17:392-397) the overall pregnancy rate was 12.7% per cycle but decreased from 14.4% before 30 years of age to 8.9% after 42 years. Of great importance, the miscarriage rate increased more than 4 X from 11.1% before 30 yrs to 45.6% after 42 years of age. This is in agreement from the data showing that men of couples that had two or more miscarriages had 4 times greater amount of sperm DNA fragmentation. (see above) (D Carroll) Remember, men’s sperm DNA integrity varies with individuals, check to see if your man is on the better or not better side.
Action Point : If the man of a TTC couple is over 40 yrs and/or has experienced infertility and/or miscarriages, do an SCSA test to determine if this is the cause.)