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Just a few years ago at a patient workshop for infertile couples, a woman asked a speaker, “Does the age of the man have an effect on pregnancy outcome?” Surprisingly, the physician said, “Sperm are just like wine – the older the better.” This view is very old school and simply incorrect!
While maternal age over 35 years is a well-known risk factor for decreased fertility, it has clearly been demonstrated that sperm DNA fragmentation increases with age. If the man of a TTC couple is over 40 yrs and/or has experienced infertility and/or miscarriages, do an SCSA test to determine if this is the cause.
Gli studi mostrano che la frammentazione del DNA aumenta con l’età (Wyrobek et al., Evenson et Wixon, 2006). In uno studio clinico di 17,000 IUI cicli (Belloc et al., 2008) (Belloc et al. (2008) RBM Online 17:392-397), il tasso generale di gravidanza era del 12.7% per cicli, ma è diminuito dal 14.4% (gli uomini di età sotto i 30 anni) all’ 8.9% (gli uomini di età superiore ai 42 anni). Segnatamente, il tasso di aborto spontaneo ha aumentato di più di quattro volte dal 11.1% al 45.6%. Questo è compatibile con i dati che mostrano che gli uomini di coppie che hanno avuto due o più aborti spontanei hanno presentato quattro volte più frammentazione del DNA spermatico. (D Carroll). Ovviamente, l’integrità del DNA spermatico maschile varia da persona a persona. Devi verificare da che parte si trova tuo marito.
Entrare in azione: Effettuare un test SCSA per determinare le cause di ciascuna delle seguenti corrispondenze: età superiore ai 40 anni e/o precedenti di infertilità e/o aborto spontaneo.
While maternal age over 35 years is a well-known risk factor for decreased fertility, it has clearly been demonstrated that sperm DNA fragmentation increases with age (Wyrobek et al, Evenson and Wixon, 2006). In a clinical study of 17,000 IUI cycles (Belloc et al, 2008) (Belloc et al (2008) RBM Online 17:392-397) the overall pregnancy rate was 12.7% per cycle but decreased from 14.4% before 30 years of age to 8.9% after 42 years. Of great importance, the miscarriage rate increased more than 4 X from 11.1% before 30 yrs to 45.6% after 42 years of age. This is in agreement from the data showing that men of couples that had two or more miscarriages had 4 times greater amount of sperm DNA fragmentation. (see above) (D Carroll) Remember, men’s sperm DNA integrity varies with individuals, check to see if your man is on the better or not better side.
Action Point : If the man of a TTC couple is over 40 yrs and/or has experienced infertility and/or miscarriages, do an SCSA test to determine if this is the cause.)